Medicinal plants contain bioactive compounds capable of preventing and fighting oxidative related diseases. Medicinal plants play a great role in human life and have substances that are used for traditional therapeutic and modern drug production purposes in primary health care delivery. Costus afer as a medicinal plant is commonly used for traditional therapeutic and other socio cultural purposes such as wrapping of indigenous food items, mat making, feed to small ruminants, treatment of cough, measles, malaria, eye defects, hunch back and evil repellants. These compounds must be screened and assayed before effective drugs are developed. Thus, phytochemical constituents and antioxidant activities of methanolic leaf extract of Costus afer ker-Gawl were evaluated. Costus afer contains Flavonoids, phenols, Tannins, Cardiac glycoside, Cardenolides, Saponins. Furthermore, Total phenolic content was 0.359±0.0225mg (gallic acid equivalent/g).For the total flavonoid content was 0.119±0.087mg(gallic acid equivalent/g).Also the methanolic extract was assay for reducing power and Fe2+ chelating activity. Nevertheless, Methanolic extract of Costus afer possess anti-oxidative properties as well as bioactive metabolite. Thus, leaf of Costus afer could serve as sources of antioxidants and bioactive compounds for nutrition and therapeutic purposes. The present study reveals that leaf of Costus afer exhibits satisfactory scavenging effect in all radical scavenging assays.

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